Is the use of a structured benefit-risk assessment framework  to evaluate an investigational product’s benefits and risks during development providing greater benefits or not?

so we had to find 3 credible articles (I attached them for your review) and for below topic: and write an annotated bibliography.
. Benefit-Risk Assessment topics
Is the use of a structured benefit-risk assessment framework  to evaluate an investigational product’s benefits and risks during development providing greater benefits or not?
here were the instructions and requirement for the assignment:

Is the use of a structured benefit-risk assessment framework  to evaluate an investigational product’s benefits and risks during development providing greater benefits or not?
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