What this essay is about: Explain the role of derivatives of carbohydrates (glucosamine and vitamin C) in the management and treatment of osteoarthritis.
The purpose of an introduction section? To provide a rationale for the topic of the essay (to say why it is important)
First paragraph:
First part of the essay:
What is the problem?
Osteoarthritis
1. The problem
The prevalence
data from statistical
Search up: epidemiology of arthritis
For statistics either use worldwide or just the UK (don’t mention the US alone).
2. Impact (not symptoms unless you relate it to the impact on their life’s)
personal
Family
Life
Quality of life
Economy
Second paragraph:
3. Risk factor
Obesity
Age
Lifestyle (diet)
Gender
Genetics
Do NOT be repetitive
Link all paragraphs – make it flow
A good way to link the third paragraph is from obesity
Third paragraph:
What is currently been done about the problem?
Treatments regimes (physical treatment can be linked with obesity)
Limitations of the treatment (link to our choice of compound like vitamin C or glucosamine (rationale) if it has solutions why do we need more?
The aims should be at the end of the introduction
Fourth paragraph: discussion – this is the main part of the essay and should focus on the chemistry aspect.
Start with an explanation of the pathophysiology of OA
Extracellular matrix
Cartilage formation and degradation
Chondrocytes involvement
5th paragraph:
The rest should be a discussion (compare) from experimental studies
Clinical trails – human studies (efficacy of the treatment effective)
In vivo – conducted on experiment animals (efficacy (species) and toxicity (VIVO – conducted on a living organism)
In vitro – conducted using immortalised (mechanism of action how it works) (cell lines)
Only compare the same topics not different ones (VITRO on non-living organisms like cells because they are living but aren’t in the body)
Resources:
pubmed
Google scholar
Jstor
