List of the Wiki page topics, Ch.18 and Ch. 19
Ch. 18 – Mechanisms of Hormonal Regulation
1. Describe the functions of the endocrine system.
2. Discuss the regulation of hormone secretion by positive and negative feedback loops.
3. Discuss the cellular mechanisms of hormone transport and hormone receptors.
4. Differentiate between up-regulation and down-regulation of hormone receptors.
5. Discuss hormone receptor binding.
6. Describe the hormones of the anterior pituitary (including the appropriate releasing factor), stimulating hormones, target hormones, and target tissues, including normal outcomes.
7. Discuss the hormones of the posterior pituitary and their actions.
8. Discuss the effects of thyroid hormone (T3, T4) and the mechanisms of thyroid hormone regulation.
9. Discuss the effects of parathyroid hormone and the mechanisms of parathyroid hormone regulation.
10. Describe the hormones secreted by the alpha, beta, and delta cells of the pancreas and discuss their major functions.
11. Discuss the adrenocortical and medullary hormones with reference to structure, function, and regulation of secretion by the body systems.
12. Describe and discuss the neuroendocrine response to stress.
Ch. 19 – Alterations of Hormonal Regulation
1. Explain three ways target cells fail to respond to hormones, creating hormonal dysfunction.
2. Compare the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and diabetes insipidus in regard to causative factors, pathophysiology, manifestations, treatment, and prognosis.
3. Discuss the causes of hyper- and hypopituitarism while considering the populations at highest risk for developing these disorders.
4. Discuss the manifestations and consequences of pituitary adenomas and prolactinomas.
5. Explain the progression of hyperthyroidism through Graves disease and thyroid storm in relation to cellular changes, manifestations, treatments, and complications.
6. Discuss the causes, treatment options, and outcomes for disorders that produce hypothyroidism.
7. Differentiate between primary and secondary hyperparathyroidism.
8. Discuss the similarities and differences in the onset, etiology, and pathophysiology of type 1 and type 2 diabetes mellitus.
9. Describe the acute complications of diabetes mellitus with a focus on differential detection and treatment.
10. Discuss the chronic complications of diabetes mellitus and discuss how good control of blood glucose limits the cellular degeneration in each instance.
11. Describe the function, uses, and mechanisms of the polyol pathway.
12. Compare hypercortical function (Cushing disease and syndrome) and hypocortical function (Addison disease), including causative factors, pathophysiology, manifestations, treatment, and prognosis.
13. Differentiate primary and secondary hyperaldosteronism.
14. Describe pathophysiology, evaluation, and treatment of Addison disease.
15. Describe tumors of the adrenal medulla.
